Assuming she was into current kinks and fetishes and the scene was not built around her size. Strapon, bondage, showers, cbt, spanking, etc.
Even a catchy name like Mistress Midget.
A simple Yes or No would do.

Yes!

I would be her slave in a instant!! Small and dominant....the ultimate obedience!

It would depend on her personality.

Like a certain character from the current MacGyver?

This is like asking, "Would a nice looking black Domme kill it?"

Not really. I am in my 50s and have seen, white, black and Asian Dommes. Go to any site for a major city and you have your pick. Most of what I have seen I consider pretty attractive.
Last session I had was in Phoenix. Assuming interests are comparable and I am in Phoenix again If I ran across someone who was 4’6” then I am lining up to serve.
But that’s just me.
This coming from someone who can say one of my favorite all time Dommes was 6’ tall.

The reason why one might pose this question is because her value is assumed to be diminished because she is smaller. It presupposes that she is not as capable of being a good one as someone who is not small.

I guess I don’t think about the power aspect. She’s the Domme and I am there to serve so stature is not my point. It could just be something different than what most of us have experienced with the Dommes we have met.
BTW, my selfish reason is, regardless of size, I am looking for someone with small slender hands for invasion. Bucket list item I need to accomplish.